R-Rsolid-0.9.31-5.fc15$>U}JV9`q >9a?Qd   g $DHWfs < t    x    <  8 (]8h 9 : GH,IXY\]T^JbFdltuLvwDxy$ HeLfOCR-Rsolid0.9.315.fc15Quantile normalization and base calling for second generation sequencing data Rsolid is an R package for normalizing fluorescent intensity data from ABI/SOLiD second generation sequencing platform. It has been observed that the color-calls provided by factory software contain technical artifacts, where the proportions of colors called are extremely variable across sequencing cycles. Under the random DNA fragmentation assumption, these proportions should be equal across sequencing cycles and proportional to the dinucleotide frequencies of the sample. Rsolid implements a version of the quantile normalization algorithm that transforms the intensity values before calling colors. Results show that after normalization, the total number of mappable reads increases by around 5%, and number of perfectly mapped reads increases by 10%. Moreover a 2-5% reduction in overall error rates is observed, with a 2-6% reduction in the rate of valid adjacent color mis-matches. The latter is important, since it leads to a decrease in false-positive SNP calls. The normalization algorithm is computationally efficient. In a test we are able to process 300 million reads in 2 hours using 10 computer cluster nodes. The engine functions of the package are written in C for better performance.Nhx86-18.phx2.fedoraproject.orgFedora ProjectFedora ProjectArtistic 2.0Fedora ProjectApplications/Engineeringhttp://rafalab.jhsph.edu/Rsolid/linuxx86_64F(cy=a BL \[PA큤A큤A큤A큤A큤A큤AN]N\N]N]N]N]N]N]N\N\N]N]N]N]N]N]N]N]N]N]N]N]N]N]N]N]N]N]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-Rsolid-0.9.31-5.fc15.src.rpmRsolid.so()(64bit)R-RsolidR-Rsolid(x86-64)@@@@@@@   @ R-corelibR.so()(64bit)libc.so.6()(64bit)libc.so.6(GLIBC_2.14)(64bit)libc.so.6(GLIBC_2.2.5)(64bit)libc.so.6(GLIBC_2.3.4)(64bit)libc.so.6(GLIBC_2.4)(64bit)libhdf5.so.6()(64bit)rpmlib(CompressedFileNames)rpmlib(FileDigests)rpmlib(PayloadFilesHavePrefix)rtld(GNU_HASH)rpmlib(PayloadIsXz)3.0.4-14.6.0-14.0-15.2-14.9.1.2Nk@M@Mc@MOLrbLZL@IL@IL;L3L@Tom Callaway - 0.9.31-5Adam Huffman - 0.9.31-4Orion Poplawski - 0.9.31-3Fedora Release Engineering - 0.9.31-2Adam Huffman - 0.9.31-1Adam Huffman - 0.9.3-1Adam Huffman - 0.9.2-4Adam Huffman - 0.9.2-3Adam Huffman - 0.9.2-2Adam Huffman - 0.9.2-1Adam Huffman - 0.9.1-1- rebuild for R 2.14.0- remove executable files to pass check- Rebuild for hdf5 1.8.7- Rebuilt for https://fedoraproject.org/wiki/Fedora_15_Mass_Rebuild- another upstream bugfix release- New upstream bugfix release- fix duplicated files entries- new upstream release with licensing clarification - specfile cleanups to address reviewer comments: - directory ownership - requires- spec formatting cleanups- new release with ability to disable bundled HDF5 - fix files section - -devel subpackage- initial package for Fedora                             !#&G&~&&&&H"&L&M&x&y&N&O&z&&|&}&&{&&&&&I&0.9.31-5.fc150.9.31-5.fc15RsolidDESCRIPTIONINDEXMetaRd.rdsdata.rdshsearch.rdslinks.rdspackage.rdsNAMESPACERRsolidRsolid.rdbRsolid.rdxdataprop.Hs.rdahelpAnIndexRsolid.rdbRsolid.rdxaliases.rdspaths.rdshtml00Index.htmlR.cssRsolid.htmllibsRsolid.so/usr/lib64/R/library//usr/lib64/R/library/Rsolid//usr/lib64/R/library/Rsolid/Meta//usr/lib64/R/library/Rsolid/R//usr/lib64/R/library/Rsolid/data//usr/lib64/R/library/Rsolid/help//usr/lib64/R/library/Rsolid/html//usr/lib64/R/library/Rsolid/libs/-O2 -g -pipe -Wall -Wp,-D_FORTIFY_SOURCE=2 -fexceptions -fstack-protector --param=ssp-buffer-size=4 -m64 -mtune=genericdrpmx86_64-redhat-linux-gnuASCII textELF 64-bit LSB shared object, x86-64, version 1 (SYSV), dynamically linked, strippedHTML document, ASCII textdirectory PRRRRRRRR xz2?p7zXZ !PH6@6$]"k%eqB]HaF:2l}S헲fWzI59G@PO2I6/պ5ux?)r`l`e5 \sSK3\If9yRQrXl]TE5kMFR(\_" ("KNQR&V.CH[)"PدDIi;INՉsҠEn;נ>C/pγ4 fw1x gex!oKՐ:@DYW&3_ua W~ХuH-)ZdHxmƻf6z§+hs&@vn8tP5ix!y5Q8[/c@R2i:CbrKi]KM߷4CGgkWP3Pȸ̲Ԩ[wgd[eW-4ȋph:uGE^ye5W2>-X(g VGA%%ENѹr\r/,=s[V*gx˦~mقiB*[ W98=wbGD.iut@I6J{uE垪YN1U9'IX"Z?2{J*A>o@pʚLx|kg?[GpDxZ:+ ەoyO g;ie#̝qww!w'Vn8!}Dpv0 -l>VD YcH<~sv'9G(X?&ꤵ:  BA^')M~We e#]QҥԆ7VdCt-g%Ȃ=\],ʞ\^'ϕpmׁP1v(tBV0 5t Ux\B_@FRt(/. oL& `7K/x. moWpc Ee.Npt|b6|HRb#FS<qƷ]{0E}o0dV#ãګ_2u.; 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